Mepiprazole, a new psychotropic drug: Effects on uptake and retention of monoamines in rat brain synaptosomes

  title={Mepiprazole, a new psychotropic drug: Effects on uptake and retention of monoamines in rat brain synaptosomes},
  author={Peter Placheta and Ernst A. Singer and W. Kriwanek and Georg Hertting},
The influence of mepiprazole (EMD 16,923), a new pyrazol-ylalkyl-piperazine derivative, on the uptake of 3H-norepinephrine (NE), 3H-dopamine (DA), and 3H-serotonin (5-HT) into rat brain synaptosomes from cerebral cortex, corpus striatum, and hypothalamus was investigated in comparison with several psychotropic drugs, including oxypertine, d-amphetamine, imipramine, desipramine, chlorimipramine, amitriptyline, and chlorpromazine in vitro. Mepiprazole was a relatively weak inhibitor of monoamine… 
3 Citations
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