Mephedrone (4-methylmethcathinone; ‘meow meow’): chemical, pharmacological and clinical issues

@article{Schifano2010Mephedrone,
  title={Mephedrone (4-methylmethcathinone; ‘meow meow’): chemical, pharmacological and clinical issues},
  author={Fabrizio Schifano and Antonio Albanese and Suzanne Fergus and Jacqueline L Stair and Paolo Deluca and Ornella Corazza and Zoe Davey and John Martin Corkery and Holger Siemann and Norbert Scherbaum and Mag{\'i} Farr{\'e} and Marta Torrens and Zsolt Demetrovics and Abdol Hamid Ghodse and Psychonaut Web Mapping and ReDNet Research Groups},
  journal={Psychopharmacology},
  year={2010},
  volume={214},
  pages={593-602}
}
BackgroundRecently, those substances deriving from the active ingredient of the Khat plant, cathinone, have been rising in popularity. Indeed, 4-methylmethcathinone (mephedrone; ‘meow meow’ and others) has been seen by some as a cheaper alternative to other classified recreational drugs.AimsWe aimed here at providing a state-of-the-art review on mephedrone history and prevalence of misuse, chemistry, pharmacology, legal status, product market appearance, clinical/management and related… 
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[Mephedrone, the new designer drug of abuse: pharmacokinetics, pharmacodynamics and clinical and forensic issues].
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This article aims to review the state-of-the-art literature of mephedrone, particularly its chemical structure, forms of presentation, pharmacokinetics, pharmacodynamics, acute intoxications, diagnosis and therapy of intoxications.
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Evaluated effects of the designer stimulant 4-methylmethcathinone in a rat model demonstrate that mephedrone has a unique pharmacological profile with both abuse liability and neurotoxic potential.
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TLDR
Synthetic cathinones exert similar, but not identical, effects to psychostimulatory drugs of abuse, which may lead to serious psychotic, neurological, cardiovascular, and sexual health consequences.
eview he effects and risks associated to mephedrone and methylone in umans : A review of the preliminary evidences
New psychoactive substances have drastically modified the world drug scene. An increasingly popular class comprises synthetic or substituted cathinones (legal highs, research chemicals, bath salts).
Human Pharmacology of Mephedrone in Comparison with MDMA
TLDR
Mephedrone elicited stimulant-like effects, euphoria, and well-being, and induced mild changes in perceptions with similar ratings to those observed after MDMA administration although effects peaked earlier and were shorter in duration.
Mephedrone, Methylone and 3,4‐Methylenedioxypyrovalerone (MDPV) Induce Conditioned Place Preference in Mice
TLDR
Findings show that mephedrone, methylone and MDPV produce CPP equal or higher than amphetamine strongly suggesting addictive properties.
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