Meperidine and lidocaine block of recombinant voltage-dependent Na+ channels: evidence that meperidine is a local anesthetic.

@article{Wagner1999MeperidineAL,
  title={Meperidine and lidocaine block of recombinant voltage-dependent Na+ channels: evidence that meperidine is a local anesthetic.},
  author={L. Wagner and M. Eaton and S. S. Sabnis and K. Gingrich},
  journal={Anesthesiology},
  year={1999},
  volume={91 5},
  pages={
          1481-90
        }
}
BACKGROUND The opioid meperidine induces spinal anesthesia and blocks nerve action potentials, suggesting it is a local anesthetic. However, whether it produces effective clinical local anesthesia in peripheral nerves remains unclear. Classification as a local anesthetic requires clinical local anesthesia but also blockade of voltage-dependent Na+ channels with characteristic features (tonic and phasic blockade and a negative shift in the voltage-dependence of steady-state inactivation… Expand
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