Meperidine and lidocaine block of recombinant voltage-dependent Na+ channels: evidence that meperidine is a local anesthetic.
@article{Wagner1999MeperidineAL, title={Meperidine and lidocaine block of recombinant voltage-dependent Na+ channels: evidence that meperidine is a local anesthetic.}, author={L. Wagner and M. Eaton and S. S. Sabnis and K. Gingrich}, journal={Anesthesiology}, year={1999}, volume={91 5}, pages={ 1481-90 } }
BACKGROUND
The opioid meperidine induces spinal anesthesia and blocks nerve action potentials, suggesting it is a local anesthetic. However, whether it produces effective clinical local anesthesia in peripheral nerves remains unclear. Classification as a local anesthetic requires clinical local anesthesia but also blockade of voltage-dependent Na+ channels with characteristic features (tonic and phasic blockade and a negative shift in the voltage-dependence of steady-state inactivation… Expand
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