Meperidine: A Critical Review

@article{Latta2002MeperidineAC,
  title={Meperidine: A Critical Review},
  author={Kenneth S Latta and Brian Ginsberg and Robert L. Barkin},
  journal={American Journal of Therapeutics},
  year={2002},
  volume={9},
  pages={53-68}
}
Meperidine was initially synthesized as an anticholinergic agent but was soon discovered to have analgesic properties. Although meperidine's anticholinergic effects were demonstrated in vivo, the anticholinergic effects on the biliary and renal tracts have not been demonstrated in vivo. Studies have clearly demonstrated that meperidine is no more efficacious in treating biliary or renal tract spasm than comparative mu opioids. The initial studies demonstrating the analgesic efficacy of… Expand
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Considering the availability of other effective analgesics with potentially fewer side effects, the use of meperidine for acute postoperative or labor pain should not be recommended. Expand
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Meperidine was first synthesized in 1939 as an M agent and almost immediately became the most commonly prescribed opiate in the United States and has the propensity to induce anxiety, hyperreflexia, and mood changes, and in large doses normeperidine can accumulate and has even been known to cause seizures. Expand
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  • 2011
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Meperidine : opioid not indicated for analgesia * Meperidina : opioide não indicado para analgesia
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Meperidine's inherent risks of both undertreating pain and causing adverse drug reactions should prompt clinicians and health organizations to restrict its use in pain management, and this case demonstrates the potential hazards that exist when using meperidine in any patient. Expand
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According to analyzed data, meperidine was the most widely used opioid for analgesic or was among the most prescribed analgesics, which shows the real need for an educative multidisciplinary action to promote awareness of me peridine risks and to decrease its prescription. Expand
Pethidine--does familiarity or evidence perpetuate its use?
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  • Medicine
  • South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
  • 2005
TLDR
Pethidine carries additional risks that ensure its declining use internationally, and the evidence questioning its analgesic efficacy, make it necessary to review its continued popular use in South Africa. Expand
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