Meperidine: A Critical Review

@article{Latta2002MeperidineAC,
  title={Meperidine: A Critical Review},
  author={Kenneth S Latta and Brian Ginsberg and Robert L. Barkin},
  journal={American Journal of Therapeutics},
  year={2002},
  volume={9},
  pages={53-68}
}
Meperidine was initially synthesized as an anticholinergic agent but was soon discovered to have analgesic properties. Although meperidine's anticholinergic effects were demonstrated in vivo, the anticholinergic effects on the biliary and renal tracts have not been demonstrated in vivo. Studies have clearly demonstrated that meperidine is no more efficacious in treating biliary or renal tract spasm than comparative mu opioids. The initial studies demonstrating the analgesic efficacy of… 
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224 Citations
Highly Influential Citations
9
Background Citations
61
Methods Citations
4
Results Citations
2

224 Citations

Analgesic Efficacy and Adverse Effects of Meperidine in Managing Postoperative or Labor Pain: A Narrative Review of Randomized Controlled Trials.
TLDR
Considering the availability of other effective analgesics with potentially fewer side effects, the use of meperidine for acute postoperative or labor pain should not be recommended.
A shift from demerol (meperidine) to dilaudid (hydromorphone) improves pain control and decreases admissions for patients in sickle cell crisis.
[Convulsion due to application of low dose meperidine: a case report].
TLDR
A 10 year old boy with a femur fraction who had normal renal function is reported who was treated with low dose meperidine due to post operative pains.
Meperidine-induced reversible retrograde amnesia.
Meperidine : opioid not indicated for analgesia * Meperidina : opioide não indicado para analgesia
TLDR
According to analyzed data, meperidine was the most widely used opioid for analgesic or was among the most prescribed analgesics, which shows the real need for an educative multidisciplinary action to promote awareness of me peridine risks and to decrease its prescription.
Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses
TLDR
Results of the current study do not support routine clinical use of IV meperidine at a dose of 1 mg/kg to horses, and its use as a sole agent at this dose, at best, must be cautiously considered.
Meperidine Misuse in a Patient with Sphincter of Oddi Dysfunction
TLDR
Meperidine's inherent risks of both undertreating pain and causing adverse drug reactions should prompt clinicians and health organizations to restrict its use in pain management, and this case demonstrates the potential hazards that exist when using meperidine in any patient.
Meperidine: opioid not indicated for analgesia
TLDR
According to analyzed data, meperidine was the most widely used opioid for analgesic or was among the most prescribed analgesics, which shows the real need for an educative multidisciplinary action to promote awareness of me peridine risks and to decrease its prescription.
Pethidine--does familiarity or evidence perpetuate its use?
  • T. KredoR. Onia
  • Medicine
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
  • 2005
TLDR
Pethidine carries additional risks that ensure its declining use internationally, and the evidence questioning its analgesic efficacy, make it necessary to review its continued popular use in South Africa.
Determinants of prescribing meperidine compared to morphine in hospitalized patients
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References

SHOWING 1-10 OF 273 REFERENCES
Meperidine: therapeutic use and toxicity.
PAIN CONSULT: PROBLEMS WITH MEPERIDINE
TLDR
Routine postoperative use of meperidine appears to be associated with mild negative mood changes, and routines should be reevaluate, as there is increasing evidence that there is another problem with me peridine-central nervous system excitatory effects.
Meperidine hydrochloride used intravenously before gastroscopy; preliminary report.
TLDR
Monat, 2 in an analysis of 3,000 cases, studied the effect of morphine, meperidine, and Pantopon in combination with atropine sulfate and pentobarbital alone as premedication and noted that, with me peridine hydrochloride given intramuscularly, the patients were euphoric, cooperative, and relaxed and that analgesia was.
Meperidine-induced delirium.
TLDR
The authors suggest that the delirium results from the excessive anticholinergic activity of meperidine or its only active metabolite, normeperidine.
Meperidine-Related Seizures Associated with Patient-Controlled Analgesia Pumps
TLDR
Mperidine administered via PCAP may be associated with seizures and an alternative analgesic should be administered when this route is used, as PCAPs are being used frequently to relieve the pain of sickle cell crisis as well as pain from many other etiologies.
Analgesic effects in human subjects of morphine, meperidina and methadon.
TLDR
The side effects and analgesic properties of methadon in combination with atropine and scopolamine were studied to determine the possible value of Methadon as a premedication agent for anesthesia.
Meperidine-induced generalized seizures with normal renal function.
TLDR
A man with normal renal function who had a tonic-clonic seizure due to meperidine that was administered for the pain of underlying chronic pancreatitis is reported here.
Relationship Between Blood Meperidine Concentrations and Analgesic Response: A Preliminary Report
TLDR
Variability in analgesic responses to intramuscularly administered meperidine has been related to variable and unpredictable blood concentrations after injection, and correlations were found between MCP and neuroticism and extroversion scores from a personality inventory and physical variables.
Effects of Renal Insufficiency on the Pharmacokinetics and Pharmacodynamics of Opioid Analgesics
TLDR
A high index of suspicion of opioid-induced toxicities should be maintained in patients who have renal dysfunction and receive opioids, and reports of adverse reactions in patients with impaired renal function.
CLINICAL EFFECTIVENESS AND SAFETY OF A NEW SYNTHETIC ANALGESIC DRUG, DEMEROL
TLDR
A year's experience has definitely indicated demerol's value as an analgesic agent, and it was therefore deemed advisable to report on its effectiveness, potency and safety.
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