Meperidine: A Critical Review

@article{Latta2002MeperidineAC,
  title={Meperidine: A Critical Review},
  author={Kenneth S Latta and Brian Ginsberg and Robert L. Barkin},
  journal={American Journal of Therapeutics},
  year={2002},
  volume={9},
  pages={53-68}
}
Meperidine was initially synthesized as an anticholinergic agent but was soon discovered to have analgesic properties. Although meperidine's anticholinergic effects were demonstrated in vivo, the anticholinergic effects on the biliary and renal tracts have not been demonstrated in vivo. Studies have clearly demonstrated that meperidine is no more efficacious in treating biliary or renal tract spasm than comparative mu opioids. The initial studies demonstrating the analgesic efficacy of… Expand
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216 Citations
Highly Influential Citations
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216 Citations

Citation Type

Citation Type

Analgesic Efficacy and Adverse Effects of Meperidine in Managing Postoperative or Labor Pain: A Narrative Review of Randomized Controlled Trials.
TLDR
Considering the availability of other effective analgesics with potentially fewer side effects, the use of meperidine for acute postoperative or labor pain should not be recommended. Expand
A shift from demerol (meperidine) to dilaudid (hydromorphone) improves pain control and decreases admissions for patients in sickle cell crisis.
TLDR
Meperidine was first synthesized in 1939 as an M agent and almost immediately became the most commonly prescribed opiate in the United States and has the propensity to induce anxiety, hyperreflexia, and mood changes, and in large doses normeperidine can accumulate and has even been known to cause seizures. Expand
[Convulsion due to application of low dose meperidine: a case report].
TLDR
A 10 year old boy with a femur fraction who had normal renal function is reported who was treated with low dose meperidine due to post operative pains. Expand
Meperidine restriction in a pediatric hospital.
  • K. Benner, Spencer H Durham
  • Medicine
  • The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
  • 2011
TLDR
Limiting meperidine's use via a restriction policy and/or removal from the institution formulary can help limit the use of this potentially toxic agent in the pediatric patient. Expand
Meperidine-induced reversible retrograde amnesia.
TLDR
Mperidine was probably associated with reversible amnesia in this healthy patient after a single therapeutic dose, and three hours after meperidine administration was discontinued, the amnesia and disorientation spontaneously resolved. Expand
Meperidine : opioid not indicated for analgesia * Meperidina : opioide não indicado para analgesia
BACKGROUND AND OBJECTIVES: Pain evaluation and the choice of the analgesic best providing its control are extremely important for patients’ quality of life. This study aimed at describing the… Expand
Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses
TLDR
Results of the current study do not support routine clinical use of IV meperidine at a dose of 1 mg/kg to horses, and its use as a sole agent at this dose, at best, must be cautiously considered. Expand
Meperidine Misuse in a Patient with Sphincter of Oddi Dysfunction
TLDR
Meperidine's inherent risks of both undertreating pain and causing adverse drug reactions should prompt clinicians and health organizations to restrict its use in pain management, and this case demonstrates the potential hazards that exist when using meperidine in any patient. Expand
Meperidine: opioid not indicated for analgesia
TLDR
According to analyzed data, meperidine was the most widely used opioid for analgesic or was among the most prescribed analgesics, which shows the real need for an educative multidisciplinary action to promote awareness of me peridine risks and to decrease its prescription. Expand
Pethidine--does familiarity or evidence perpetuate its use?
  • T. Kredo, R. Onia
  • Medicine
  • South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
  • 2005
TLDR
Pethidine carries additional risks that ensure its declining use internationally, and the evidence questioning its analgesic efficacy, make it necessary to review its continued popular use in South Africa. Expand
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References

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TLDR
Meperidine is a synthetic opioid analgesic frequently prescribed in the emergency department, and should be considered a second line agent in the treatment of pain when opioid analgesics are required. Expand
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TLDR
Routine postoperative use of meperidine appears to be associated with mild negative mood changes, and routines should be reevaluate, as there is increasing evidence that there is another problem with me peridine-central nervous system excitatory effects. Expand
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TLDR
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TLDR
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TLDR
Mperidine administered via PCAP may be associated with seizures and an alternative analgesic should be administered when this route is used. Expand
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TLDR
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TLDR
A man with normal renal function who had a tonic-clonic seizure due to meperidine that was administered for the pain of underlying chronic pancreatitis is reported here. Expand
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TLDR
Variability in analgesic responses to intramuscularly administered meperidine has been related to variable and unpredictable blood concentrations after injection, and correlations were found between MCP and neuroticism and extroversion scores from a personality inventory and physical variables. Expand
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TLDR
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TLDR
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