Meperidine: A Critical Review

@article{Latta2002MeperidineAC,
  title={Meperidine: A Critical Review},
  author={Kenneth S Latta and Brian Ginsberg and Robert L. Barkin},
  journal={American Journal of Therapeutics},
  year={2002},
  volume={9},
  pages={53-68}
}
Meperidine was initially synthesized as an anticholinergic agent but was soon discovered to have analgesic properties. Although meperidine's anticholinergic effects were demonstrated in vivo, the anticholinergic effects on the biliary and renal tracts have not been demonstrated in vivo. Studies have clearly demonstrated that meperidine is no more efficacious in treating biliary or renal tract spasm than comparative mu opioids. The initial studies demonstrating the analgesic efficacy of… 
Analgesic Efficacy and Adverse Effects of Meperidine in Managing Postoperative or Labor Pain: A Narrative Review of Randomized Controlled Trials.
TLDR
Considering the availability of other effective analgesics with potentially fewer side effects, the use of meperidine for acute postoperative or labor pain should not be recommended.
A shift from demerol (meperidine) to dilaudid (hydromorphone) improves pain control and decreases admissions for patients in sickle cell crisis.
[Convulsion due to application of low dose meperidine: a case report].
TLDR
A 10 year old boy with a femur fraction who had normal renal function is reported who was treated with low dose meperidine due to post operative pains.
Meperidine-induced reversible retrograde amnesia.
Meperidine : opioid not indicated for analgesia * Meperidina : opioide não indicado para analgesia
TLDR
According to analyzed data, meperidine was the most widely used opioid for analgesic or was among the most prescribed analgesics, which shows the real need for an educative multidisciplinary action to promote awareness of me peridine risks and to decrease its prescription.
Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses
TLDR
Results of the current study do not support routine clinical use of IV meperidine at a dose of 1 mg/kg to horses, and its use as a sole agent at this dose, at best, must be cautiously considered.
Meperidine Misuse in a Patient with Sphincter of Oddi Dysfunction
TLDR
Meperidine's inherent risks of both undertreating pain and causing adverse drug reactions should prompt clinicians and health organizations to restrict its use in pain management, and this case demonstrates the potential hazards that exist when using meperidine in any patient.
Meperidine: opioid not indicated for analgesia
TLDR
According to analyzed data, meperidine was the most widely used opioid for analgesic or was among the most prescribed analgesics, which shows the real need for an educative multidisciplinary action to promote awareness of me peridine risks and to decrease its prescription.
Pethidine--does familiarity or evidence perpetuate its use?
  • T. KredoR. Onia
  • Medicine
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
  • 2005
TLDR
Pethidine carries additional risks that ensure its declining use internationally, and the evidence questioning its analgesic efficacy, make it necessary to review its continued popular use in South Africa.
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TLDR
Routine postoperative use of meperidine appears to be associated with mild negative mood changes, and routines should be reevaluate, as there is increasing evidence that there is another problem with me peridine-central nervous system excitatory effects.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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