Mentholated Cigarette Smoking Inhibits Nicotine Metabolism

@article{Benowitz2004MentholatedCS,
  title={Mentholated Cigarette Smoking Inhibits Nicotine Metabolism},
  author={Neal L. Benowitz and Brenda Herrera and Peyton Jacob},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2004},
  volume={310},
  pages={1208 - 1215}
}
Smoking mentholated cigarettes has been suggested to convey a greater cancer risk compared with smoking nonmentholated cigarettes. Two of the possible mechanisms by which mentholated cigarette smoking could increase risk are by increasing systemic exposure to tobacco smoke toxins and by affecting the metabolism of nicotine or tobacco smoke carcinogens. To examine these possibilities, we performed a crossover study in 14 healthy smokers, one-half of whom were African-Americans and one-half… 
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TLDR
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TLDR
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TLDR
Results show that menthol does not affect biological exposure to tobacco smoke constituents but indicates that Menthol might inhibit the detoxification of the potent lung carcinogen NNAL, which is a possible indicator of lung cancer risk.
Up-regulation of nicotinic acetylcholine receptors in menthol cigarette smokers.
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Study results demonstrate that menthol smokers have greater up-regulation of nAChRs than non-menthol smokers, presumably related to higher nicotine exposure in menthol smoker, although other mechanisms for menthol influencing receptor density are possible.
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