Menthol shares general anesthetic activity and sites of action on the GABA(A) receptor with the intravenous agent, propofol.

@article{Watt2008MentholSG,
  title={Menthol shares general anesthetic activity and sites of action on the GABA(A) receptor with the intravenous agent, propofol.},
  author={Erin Elizabeth Watt and Brooke A Betts and Francesca O. Kotey and Danielle J Humbert and Theanne N. Griffith and Elizabeth W. Kelly and Kelley C Veneskey and Nikhila Gill and Kathleen C. Rowan and Andrew Tobias Aveling Jenkins and Adam C. Hall},
  journal={European journal of pharmacology},
  year={2008},
  volume={590 1-3},
  pages={
          120-6
        }
}
Menthol and related compounds were investigated for modulation of recombinant human gamma-aminobutyric acid type A (GABA(A), alpha(1)beta(2)gamma(2s)) receptor currents expressed in Xenopus oocytes. Sub-maximal (EC(20)) GABA currents were typically enhanced by co-applications of 3-300 microM (+)-menthol (e.g. by approximately 2-fold at 50 microM) > isopulegol > isomenthol> alpha-terpineol >> cyclohexanol. We studied menthol's actions on GABA(A) receptors compared to sedatives (benzodiazepines… CONTINUE READING
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