Menthol induces cell death via the TRPM8 channel in the human bladder cancer cell line T24.

@article{Li2009MentholIC,
  title={Menthol induces cell death via the TRPM8 channel in the human bladder cancer cell line T24.},
  author={Qin Li and Xinghuan Wang and Zhonghua Yang and Bin Wang and Shilin Li},
  journal={Oncology},
  year={2009},
  volume={77 6},
  pages={335-41}
}
OBJECTIVE Growing evidence has shown that menthol has potent anticancer activity in various human cancers via the transient receptor potential melastatin 8 (TRPM8)-dependent pathway or in a TRPM8-independent manner. However, its effect on bladder cancer remains obscure. In the present investigation, we examined the expression of TRPM8 and the role of menthol in cells of the human bladder cancer cell line T24. METHODS RT-PCR, Western blotting and immunocytochemistry were used to confirm the… CONTINUE READING
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