Menthol: a refreshing look at this ancient compound.

  title={Menthol: a refreshing look at this ancient compound.},
  author={Tejesh S. Patel and Yozo Ishiuji and Gil Yosipovitch},
  journal={Journal of the American Academy of Dermatology},
  volume={57 5},
Menthol is a naturally occurring cyclic terpene alcohol of plant origin, which has been used since antiquity for medicinal purposes. Its use in dermatology is ubiquitous, where it is frequently part of topical antipruritic, antiseptic, analgesic, and cooling formulations. Despite its widespread use, it was only recently that the mechanism by which menthol elicits the same cool sensation as low temperature was elucidated upon, with the discovery of the TRPM8 receptor. Although almost 5 years… CONTINUE READING

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