Menthol: a natural analgesic compound.

  title={Menthol: a natural analgesic compound.},
  author={Nicoletta Galeotti and Lorenzo Di Cesare Mannelli and Gabriela Mazzanti and Alessandro Bartolini and Carla Ghelardini},
  journal={Neuroscience letters},
  volume={322 3},
Menthol, after topical application, causes a feeling of coolness due to stimulation of 'cold' receptors by inhibiting Ca++ currents of neuronal membranes. Since Ca++ channel blockers are endowed with analgesic properties, the aim of the present study was to investigate the potential antinociceptive effect of menthol. (-)-Menthol produced a dose-dependent increase in the pain threshold in the mouse hot-plate (3-10 mg kg(-1) p.o.) and abdominal constriction (3-10 mg kg(-1) p.o.; 10 microg per… CONTINUE READING


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