Menthol: a natural analgesic compound

  title={Menthol: a natural analgesic compound},
  author={N. Galeotti and L. Mannelli and G. Mazzanti and A. Bartolini and C. Ghelardini},
  journal={Neuroscience Letters},
  • N. Galeotti, L. Mannelli, +2 authors C. Ghelardini
  • Published 2002
  • Medicine
  • Neuroscience Letters
  • Menthol, after topical application, causes a feeling of coolness due to stimulation of 'cold' receptors by inhibiting Ca++ currents of neuronal membranes. Since Ca++ channel blockers are endowed with analgesic properties, the aim of the present study was to investigate the potential antinociceptive effect of menthol. (-)-Menthol produced a dose-dependent increase in the pain threshold in the mouse hot-plate (3-10 mg kg(-1) p.o.) and abdominal constriction (3-10 mg kg(-1) p.o.; 10 microg per… CONTINUE READING
    Central Mechanisms of Menthol-Induced Analgesia
    • 48
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    Inhibition by menthol and its related chemicals of compound action potentials in frog sciatic nerves.
    • 44
    • Highly Influenced
    Menthol Binding and Inhibition of α7-Nicotinic Acetylcholine Receptors
    • 44
    Menthol Inhibits 5-HT3 Receptor–Mediated Currents
    • 31
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    TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain
    • 122
    • Highly Influenced
    • PDF
    Bimodal Action of Menthol on the Transient Receptor Potential Channel TRPA1
    • 368
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    Publications referenced by this paper.
    Menthol and Related Cooling Compounds
    • 387