Menthol: a natural analgesic compound

@article{Galeotti2002MentholAN,
  title={Menthol: a natural analgesic compound},
  author={N. Galeotti and L. Mannelli and G. Mazzanti and A. Bartolini and C. Ghelardini},
  journal={Neuroscience Letters},
  year={2002},
  volume={322},
  pages={145-148}
}
  • N. Galeotti, L. Mannelli, +2 authors C. Ghelardini
  • Published 2002
  • Medicine
  • Neuroscience Letters
  • Menthol, after topical application, causes a feeling of coolness due to stimulation of 'cold' receptors by inhibiting Ca++ currents of neuronal membranes. Since Ca++ channel blockers are endowed with analgesic properties, the aim of the present study was to investigate the potential antinociceptive effect of menthol. (-)-Menthol produced a dose-dependent increase in the pain threshold in the mouse hot-plate (3-10 mg kg(-1) p.o.) and abdominal constriction (3-10 mg kg(-1) p.o.; 10 microg per… CONTINUE READING
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    Menthol Inhibits 5-HT3 Receptor–Mediated Currents
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    TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain
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    Bimodal Action of Menthol on the Transient Receptor Potential Channel TRPA1
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