Mentalizing impairment in schizophrenia: A functional MRI study

@article{Das2012MentalizingII,
  title={Mentalizing impairment in schizophrenia: A functional MRI study},
  author={Pritha Das and Jim Lagopoulos and Carissa M. Coulston and Antony F. Henderson and Gin S. Malhi},
  journal={Schizophrenia Research},
  year={2012},
  volume={134},
  pages={158-164}
}
Mentalizing in schizophrenia: A multivariate functional MRI study
An fMRI study of theory of mind in individuals with first episode psychosis
Theory of Mind impairments in early course schizophrenia: An fMRI study.
Neurofunctional Correlates of Theory of Mind Deficits in Schizophrenia
TLDR
The issue of neurofunctional correlates of Theory of Mind deficits in schizophrenia is addressed by reviewing functional imaging studies of the past ten years comparing schizophrenia patients to healthy controls, and several differences in hemodynamic response between patients and controls were observed.
Hyper- and Hypomentalizing in Patients with First-Episode Schizophrenia: fMRI and Behavioral Studies
TLDR
The neural pattern of FES patients is consistent with deficits in the ability to switch off mentalizing processes in potentially social contexts, instead increasing them when intentionality is not forthcoming, demonstrating complexities of theory of mind deficits in schizophrenia that should be considered when offering social cognitive training programs.
White Matter Correlates of Theory of Mind in Patients With First-Episode Psychosis
TLDR
This study is the first to demonstrate the white matter connectivity underlying the mentalizing network, as well as its relation to ToM ability in patients with FEP.
Neural and behavioral effects of oxytocin administration during theory of mind in schizophrenia and controls: a randomized control trial
TLDR
RTPJ activity during ToM might be a potential neural target for the treatment of social cognitive deficits in schizophrenia, and a significant positive correlation was found between oxytocin induced increases in rTPJActivity and accuracy, indicating that oxytoc in improved rTPj activity in schizophrenia predicted behavioral improvement.
Impaired Right Temporoparietal Junction-Hippocampus Connectivity in Schizophrenia and Its Relevance for Generating Representations of Other Minds.
TLDR
Structural and functional magnetic resonance imaging and a modified prisoner's dilemma game are used together to test the hypotheses, that patients show dysfunctional social updating on behavioral level accompanied by altered rTPJ-hippocampus coupling in schizophrenia, suggesting that a neural pathway relevant for updating social knowledge and forming forward predictions in social interactions is altered in schizophrenia.
Theory of mind network activity is altered in subjects with familial liability for schizophrenia.
As evidenced by a multitude of studies, abnormalities in Theory of Mind (ToM) and its neural processing might constitute an intermediate phenotype of schizophrenia. If so, neural alterations during
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References

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TLDR
It is still under debate how an impaired ToM in schizophrenia is associated with other aspects of cognition, how the impairment fluctuates with acuity or chronicity of the schizophrenic disorder, and how this affects the patients' use of language and social behavior.
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TLDR
The areas of lower flow are consistent with previous studies indicating impairment in recruiting cortical-cerebellar circuitry in schizophrenia and a need to draw on the right hemisphere to compensate for deficits in left hemisphere networks that include frontal cortex, anterior cingulate, cerebellum, and thalamus.
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TLDR
This is the first functional MRI study to show a deficit in the left prefrontal cortex in schizophrenia during a socioemotional task, and it is suggested that patients with schizophrenia have a dysfunction in brain regions responsible for mental state attribution.
Is Theory of Mind in Schizophrenia More Strongly Associated with Clinical and Social Functioning than with Neurocognitive Deficits?
TLDR
ToM measures of social cognition may be a useful addition to neuropsychological assessment when developing programmes for reducing clinical impairments and improving the community functioning of subjects with schizophrenic disorders.
Theory of mind in schizophrenia: A critical review
TLDR
There is considerable evidence that ToM is impaired in people with schizophrenia, however, this is perhaps the only unequivocal finding on the topic to date.
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TLDR
This meta-analysis showed significant and stable mentalising impairment in schizophrenia and the finding that patients in remission are also impaired favours the notion thatmentalising impairment represents a possible trait marker of schizophrenia.
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TLDR
The findings of this novel neuroimaging study suggest that in a social context, euthymic bipolar patients are perhaps constrained in their ability to mentalize fully, and furthermore cannot reliably adopt an alternate cognitive perspective when appropriate.
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