Menstrual cycle and ovary alterations in women with epilepsy on antiepileptic therapy

  title={Menstrual cycle and ovary alterations in women with epilepsy on antiepileptic therapy},
  author={Giovanni Murialdo and Carlo Andrea Galimberti and Flavia Magri and Patrizia Sampaolo and Francesco Copello and Maria Vittoria Gianelli and Elisabetta Gazzerro and Alessandro Rollero and C. Deagatone and Raffaele Manni and Ettore Ferrari and Alessandro Polleri and Amelia Tartara},
  journal={Journal of Endocrinological Investigation},
Impaired reproductive function is thought to frequently affect women with epilepsy, mainly when seizures originate in the temporal lobe. In this study, we evaluated menstrual cycle features and assessed ovulation by determining luteal progesterone (Pg) levels in 101 consecutive women with epilepsy (36 with idiopathic generalized epilepsy -IGE; 65 with partial epilepsy -PE), aged between 16 and 50 years, treated with various antiepileptic drugs (AED). PE originated in the temporal lobe (TLE) in… 
Reproductive dysfunction in women with epilepsy
Treatment with these agents should be considered in women who develop reproductive endocrine dysfunction during treatment with the older AEDs, including phenytoin and carbamazepine, which may result in menstrual disorders in some women receiving long-term CBZ treatment.
Characterization of reproductive endocrine disorders in women with epilepsy.
The results of this study suggest that the prevalence of disordered ovulation, in particular polycystic ovary syndrome, is increased in epilepsy, independent of antiepileptic medications or type of seizure disorder.
Valproate-associated reproductive and metabolic abnormalities: are epileptic women at greater risk than bipolar women?
Effect of Antiepileptic Drugs on Reproductive Endocrine Function in Individuals with Epilepsy
In women, use of valproic acid appears to be associated with a frequent occurrence of reproductive endocrine disorders characterised by polycystic changes in the ovaries, high serum testosterone concentrations (hyperandrogenism) and menstrual disorders, and from a practical point of view, the length of the menstrual cycles and body weight should be monitored in women with epilepsy after commencement of treatment with valProic acid.
Long-Term Effects of Valproic Acid on Reproductive Endocrine Functions in Turkish Women with Epilepsy
No statistically significant dose or duration-related rise of risk for patients who developed PCOS and menstrual irregularities and those who were not on long-term VPA therapy support the hypothesis of early occurring VPA-associated metabolic and endocrine changes.
Reproductive health in patients with epilepsy
Epilepsy in women.
  • M. Morrell
  • Medicine, Psychology
    American family physician
  • 2002
Epilepsy in women raises special reproductive and general health concerns and children who are born to women with epilepsy are at greater risk of birth defects, in part related to maternal use of antiepileptic drugs.
Menstrual disorders in women with epilepsy
The intricate relationship between reproductive disorders and epilepsy suggests that reproductive function should be monitored closely as part of the comprehensive care of women with epilepsy.


Reproductive Endocrine Disorders in Women with Primary Generalized Epilepsy
The hormonal alterations observed in the patients with normal menstrual cycles seem to support the hypothesis that a neurotransmitter dysfunction might be the common pathogenetic mechanism resulting in both REDs and PGE.
Polycystic Ovaries and Hyperandrogenism in Women Taking Valproate for Epilepsy
This Finland study studied 238 women with epilepsy who were seen regularly at the Outpatient Department of the University Hospital, Oulu, Finland and found that menstrual disturbances were present in 13 of the women receiving valproate alone.
Ovulatory Function in Epilepsy
The results suggest a mechanism of infertility related to temporal lobe dysfunction that alters the release of hypothalamic trophic hormones that secondarily affect release of the pituitary gonadotropins, causing ovulatory failure.
Altered pulsatile secretion of luteinizing hormone in women with epilepsy
The findings suggest that LH pulse frequencies in women with TLE may be influenced by the laterality of the epileptic focus, the reproductive endocrine status, and the use of antiseizure medications.
Ovarian hormones, anticonvulsant drugs, and seizures during the menstrual cycle in women with epilepsy.
The effect of progesterone deficit on seizure susceptibility before menstrual bleeding is discussed, and the need of serum anticonvulsant level determination during the premenstrual phase in epileptic women is suggested.
Reduced fertility and neuroendocrine dysfunction in women with epilepsy.
It is suggested that epilepsy may interfere with the functional activity of the gonadotropin releasing hormone (GnRH) pulse generator, which might give rise to a clinical reproductive endocrine disorder in epileptic women.
Obesity and endocrine disorders in women taking valproate for epilepsy
The weight gain can be progressive, and is associated with hyperinsulinemia and low serum levels of insulin‐like growth factor‐binding protein 1, which may lead to hyperandrogenism and polycystic ovaries.
Reproductive endocrine disorders in men with partial seizures of temporal lobe origin.
Twenty consecutive men with partial seizures of temporal lobe origin were evaluated for sexual or reproductive dysfunction. Eleven (55%) had diminished sexual interest or reduced potency. Nine of
A relationship between particular reproductive endocrine disorders and the laterality of epileptiform discharges in women with epilepsy
Relationships between altered patterns of reproductive hormonal secretion and the predominant laterality of EEG epileptiform discharges in women with epilepsy are consistent with a lateralized asymmetry in cerebral influences on reproductive endocrine function.