Meniscus structure in human, sheep, and rabbit for animal models of meniscus repair

@article{Chevrier2009MeniscusSI,
  title={Meniscus structure in human, sheep, and rabbit for animal models of meniscus repair},
  author={Anik Chevrier and Monica Iliescu Nelea and Mark B. Hurtig and Caroline D. Hoemann and Michael D. Buschmann},
  journal={Journal of Orthopaedic Research},
  year={2009},
  volume={27}
}
Meniscus injury is a frequently encountered clinical orthopedic issue and is epidemiologically correlated to osteoarthritis. The development of new treatments for meniscus injury is intimately related to the appropriateness of animal models for their investigation. The purpose of this study was to structurally compare human menisci to sheep and rabbit menisci to generate pertinent animal models for meniscus repair. Menisci were analyzed histologically, immunohistochemically, and by… 
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Anatomical study: comparing the human, sheep and pig knee meniscus
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Sheep meniscal dimensions more closely matched human menisc dimensions than the pig meniscus, and this information may help guide the choice of an animal proxy in meniscal research.
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The macroscopic and histologic similarities between equine and human menisci described in this study, support continued research in this field and support the horse as suitable translational animal model for (human) meniscus tissue engineering.
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* The Ovine Model for Meniscus Tissue Engineering: Considerations of Anatomy, Function, Implantation, and Evaluation.
TLDR
The anatomical and compositional similarities between human and sheep menisci are established and guidance for implantation and evaluation of such devices are provided and the ovine model is recommended as the gold standard for preclinical evaluation of meniscus replacement devices.
Which Contributes to Meniscal Repair, the Synovium or the Meniscus? An In Vivo Rabbit Model Study With the Freeze-Thaw Method
TLDR
It is concluded thatsynovial cells are the primary contributors to meniscal injury repair and increasing the synovial activity and contribution should be the main objective of meniscal tissue engineering.
Viscoelastic properties of rabbit osteoarthritic menisci: A correlation with matrix alterations.
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TLDR
This review summarizes the gross anatomy, function, ultrastructure and biochemical composition of the knee meniscus in several animal models in comparison with the human meniscal structure.
Marrow stimulation improves meniscal healing at early endpoints in a rabbit meniscal injury model.
  • M. Driscoll, Brett N. Robin, +5 authors R. Reeve
  • Medicine, Biology
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • 2013
Augmentation Techniques for Meniscus Repair
TLDR
The current state of clinical management of meniscus tears (primary repair) as well as augmentation techniques to improve healing by meniscUS wrapping with extracellular matrix materials, trephination, synovial rasping and abrasion, fibrin/blood clot placement, and platelet‐rich plasma injections are reviewed.
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