Meningococcemia and purpura fulminans in adults: Acute deficiencies of proteins C and S and early treatment with antithrombin III concentrates

@article{Fourrier1990MeningococcemiaAP,
  title={Meningococcemia and purpura fulminans in adults: Acute deficiencies of proteins C and S and early treatment with antithrombin III concentrates},
  author={F. Fourrier and P. Lestavel and C. Chopin and A. Marey and J. Goudemand and A. Rime and J. Mangalaboyi},
  journal={Intensive Care Medicine},
  year={1990},
  volume={16},
  pages={121-124}
}
It has been recently suggested that an acquired deficiency of proteins C and S could contribute to the pathogenesis of meningococcemic purpura fulminans (PF) in children. Our study was designed to measure the levels of antithrombin III (AT III), protein C, and protein S during adult PF and to determine the effects of an early infusion of high doses of AT III concentrates on clinical and biological alterations of PF. We studied five consecutive adult patients with meningococcemia (type B) and PF… Expand
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