Meningococcal vaccines.

  title={Meningococcal vaccines.},
  author={Lisa Danzig},
  journal={The Pediatric infectious disease journal},
  volume={23 12 Suppl},
  • Lisa Danzig
  • Published 2004 in The Pediatric infectious disease journal
BACKGROUND The 5 major pathogenic serogroups of the Gram-negative encapsulated bacterium Neisseria meningitidis are A, B, C, Y, and W135. In the 1960s, vaccines consisting of purified capsular polysaccharide antigens were developed against serogroups A, C, Y, and W135. These vaccines were highly effective among adults but were not efficacious among infants and young children. Capsular polysaccharide-protein conjugate vaccines were subsequently developed. METHODS The development of second… CONTINUE READING


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