Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium.

@article{Coureuil2009MeningococcalTI,
  title={Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium.},
  author={Mathieu Coureuil and Guillain Mikaty and Florence Miller and Herv{\'e} L{\'e}cuyer and Christine Bernard and Sandrine Bourdoulous and Guillaume Dum{\'e}nil and Ren{\'e} Marc M{\`e}ge and Babette Weksler and Ignacio Andres Romero and P Olivier Couraud and Xavier Nassif},
  journal={Science},
  year={2009},
  volume={325 5936},
  pages={83-7}
}
Type IV pili mediate the initial interaction of many bacterial pathogens with their host cells. In Neisseria meningitidis, the causative agent of cerebrospinal meningitis, type IV pili-mediated adhesion to brain endothelial cells is required for bacteria to cross the blood-brain barrier. Here, type IV pili-mediated adhesion of N. meningitidis to human brain endothelial cells was found to recruit the Par3/Par6/PKCzeta polarity complex that plays a pivotal role in the establishment of eukaryotic… CONTINUE READING
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Described in the Supporting Online Material: Materials and methods section

VL Madgula, B Avula, VLN Reddy, IA Khan, Med Khan SI . Planta
2007

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