Meningococcal disease and the complement system

  title={Meningococcal disease and the complement system},
  author={Lisa A Lewis and Sanjay Ram},
Despite considerable advances in the understanding of the pathogenesis of meningococcal disease, this infection remains a major cause of morbidity and mortality globally. The role of the complement system in innate immune defenses against invasive meningococcal disease is well established. Individuals deficient in components of the alternative and terminal complement pathways are highly predisposed to invasive, often recurrent meningococcal infections. Genome-wide analysis studies also point to… CONTINUE READING