Meningococcal disease and sexual transmission: urogenital and anorectal infections and invasive disease due to Neisseria meningitidis

  title={Meningococcal disease and sexual transmission: urogenital and anorectal infections and invasive disease due to Neisseria meningitidis
  author={Shamez N. Ladhani and Jay Lucidarme and Sydel R. Parikh and Helen Campbell and Ray Borrow and Mary E Ramsay},
  journal={The Lancet},

Symptomatic Female Genital Tract Infections Due to Neisseria meningitidis in Athens, Greece

This is the first report in Greece, and, to the authors' knowledge, in Europe since 2005 describing meningococcal female genital infections, and it is warned not to exclude N. meningitidis from routine diagnosis and the need of early detection.

The Host-Pathogen Interactions and Epicellular Lifestyle of Neisseria meningitidis

This review focuses on the competition that N. meningitidis faces in the nasopharynx from other Neisseria species, and how the genetic diversity of the meningococcus contributes to the wide range of inflammatory and pathogenic potentials observed among different lineages.

Evaluation of Urethrotropic-Clade Meningococcal Infection by Urine Metagenomic Shotgun Sequencing

Urethral infections caused by an emerging nongroupable (NG) urethrotropic clade of Neisseria meningitidis were first reported in the United States in 2015 (the “U.S. ABSTRACT Urethral infections

Oral and anal carriage of Neisseria meningitidis among sexually active HIV-infected men who have sex with men in Denmark 2014-15.

  • M. TinggaardH. Slotved T. Benfield
  • Medicine, Biology
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
  • 2021

Molecular characterisation and antibiotic susceptibility of meningococcal isolates from healthy men who have sex with men

Serogroup B meningococcal carriage identified from oral and anal specimens among healthy men who have sex with men (MSM) was the most frequent serogroup identified in this study.

Reactive vaccination as control strategy for an outbreak of invasive meningococcal disease caused by Neisseria meningitidis C:P1.5-1,10-8:F3-6:ST-11(cc11), Bergamo province, Italy, December 2019 to January 2020

  • C. FazioL. Daprai P. Stefanelli
  • Medicine, Biology
    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
  • 2022
The phylogenetic evaluation demonstrated the close genetic proximity between the strain involved in this outbreak and a strain responsible for a larger epidemic that had occurred in 2015 and 2016 in the Tuscany Region.

Evolution of ST-4821 clonal complex hyperinvasive and quinolone-resistant meningococci: the next meningococcal pandemic?

The increasing global distribution of B:cc4821 meningococci raises concern that cc4821 has the potential to cause a global pandemic and, this would be challenging to control though there is indirect evidence that Trumenba® vaccine might afford some protection.

Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci

The increasing distribution worldwide of serogroup BCC4821 raises the concern that CC4821 has the potential to cause a pandemic that would be challenging to control, despite indirect evidence that the Trumenba vaccine might afford some protection.

Neisseria meningitidis Urethritis Outbreak Isolates Express a Novel Factor H Binding Protein Variant That Is a Potential Target of Group B-Directed Meningococcal (MenB) Vaccines

A new FHbp variant, peptide allele identification no. 896 (ID 896), was highly expressed by an emerging meningococcal pathotype, the nonencapsulated ure arthritis clade (US_NmUC), which has been responsible for outbreaks of urethritis in multiple U.S. cities since 2015, other mucosal infections, and cases of invasive meningitis disease.

Clinical Conundrum: Neisseria meningitidis Septic Abortion.



Emergence of a new Neisseria meningitidis clonal complex 11 lineage 11.2 clade as an effective urogenital pathogen

The clade isolates causing urethritis clusters in the United States may have adapted to the urogenital environment with two unique molecular fingerprints: the insertion of IS1301 with associated deletion of capsule, enhancing mucosal adherence, and the acquisition of the gonococcal denitrification pathway by gene conversion, promoting anaerobic growth.

Neisseria meningitidis in Specimens From Urogenital Sites: Is Increased Awareness Necessary?

During the period of this study (August 1989-March 1990), the three meningococcal strains observed at the authors' laboratory represented 20% of the total number of urogenital isolates of pathogenic Neisseria.

Meningococcal urethritis in a heterosexual man

The isolation of Neisseria meningitidis in pure culture from a heterosexual man with acute urethritis is reported here, showing that the isolate was sensitive to tetracycline, spectinomycin, ceftriaxone and ciprofloxacin.

Large Cluster of Neisseria meningitidis Urethritis in Columbus, Ohio, 2015

  • J. BazanA. Turner Xin Wang
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2017
This study investigates the epidemiologic characteristics of men with Nm urethritis and the molecular and phylogenetic characteristics of their Nm isolates and concludes that future urogenital Nm infection studies should focus on pathogenesis and modes of sexual transmission.

Expansion of a urethritis-associated Neisseria meningitidis clade in the United States with concurrent acquisition of N. gonorrhoeae alleles

Interspecies genetic recombination contributed to the early evolution and subsequent diversification of the U.S. NmNG ure arthritis clade and may facilitate the expansion of its ecological niche while also increasing the frequency with which it causes urethritis.

Prevalence and site-pathogen studies of Neisseria meningitidis and N gonorrhoeae in homosexual men.

Prevalence and site-pathogen studies of pathogenic Neisseria were conducted in 815 homosexual men over a 12-month period, finding that N meningitidis urethral isolates were associated with Urethral discharge in five of six patients, and N meneditidis in the oropharynx or rectum was not usually associated with clinical illness.

Urethritis Due to Neisseria Meningitidis in a London Genitourinary Medicine Clinic Population

In the study population the prevalence of N. meningitidis infection was low and restricted to homosexual men; however, it may be associated with symptoms.

Evolutionary Events Associated with an Outbreak of Meningococcal Disease in Men Who Have Sex with Men

The data suggest that urethritis and outbreak isolates followed a joint adaptation route including adaption to the urogenital tract, similar to other outbreaks of meningococcal disease in Europe.

Asymptomatic meningococcal urethritis. Possible protective value against gonococcal infection by bacteriocin production.

The strain isolated from this patient is the first meningococcus reported to produce a bacteriocin with antigonococcal activity, and evidence is presented for the possible role of this bacteriOCin in providing protection against gonococcal urethritis in vivo.

Urethritis Caused by Novel Neisseria meningitidis Serogroup W in Man Who Has Sex with Men, Japan

A case of urethritis caused by a novel multilocus sequence type (ST), 10651, of the ST11/electrophoretic type (ET)–37 complex Neisseria meningitidis serotype W is reported, a man who has sex with men, who was colonized with the same bacteria.