Meningococcal Outer Membrane Protein NhhA Triggers Apoptosis in Macrophages

  title={Meningococcal Outer Membrane Protein NhhA Triggers Apoptosis in Macrophages},
  author={Mikael Sj{\"o}linder and Georg Altenbacher and Matthias Hagner and Wei Sun and Sophia Schedin-Weiss and Hong S. Sj{\"o}linder},
  booktitle={PloS one},
Phagocytotic cells play a fundamental role in the defense against bacterial pathogens. One mechanism whereby bacteria evade phagocytosis is to produce factors that trigger apoptosis. Here we identify for the first time a meningococcal protein capable of inducing macrophage apoptosis. The conserved meningococcal outer membrane protein NhhA (Neisseria hia/hsf homologue A, also known as Hsf) mediates bacterial adhesion and interacts with extracellular matrix components heparan sulphate and laminin… CONTINUE READING