Meningeal myeloma deposits adversely impact the therapeutic index of an oncolytic VSV

@inproceedings{Yarde2013MeningealMD,
  title={Meningeal myeloma deposits adversely impact the therapeutic index of an oncolytic VSV},
  author={Danielle N. Yarde and Shruthi K Naik and Rebecca A. Nace and K F Peng and Mark J. Federspiel and Stephen Russell},
  booktitle={Cancer Gene Therapy},
  year={2013}
}
Vesicular stomatitis virus (VSV) is neuropathogenic in rodents but can be attenuated 50-fold by engineering the mouse interferon-beta (IFN-β) gene into its genome. Intravenously administered VSVs encoding IFN-β have potent activity against subcutaneous tumors in the 5TGM1 mouse myeloma model, without attendant neurotoxicity. However, when 5TGM1 tumor cells were seeded intravenously, virus-treated mice with advanced myeloma developed clinical signs suggestive of meningoencephalitis. Co… CONTINUE READING
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