Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology.

  title={Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology.},
  author={Roberta Magliozzi and Owain W. Howell and Abhilash Vora and Barbara Serafini and Richard S. Nicholas and Maria Puopolo and Richard Reynolds and Francesca Aloisi},
  journal={Brain : a journal of neurology},
  volume={130 Pt 4},
Intrathecal antibody production is a hallmark of multiple sclerosis and humoral immunity is thought to play an important role in the inflammatory response and development of demyelinated lesions. [] Key Method A detailed immunohistochemical and morphometric analysis was performed on post-mortem brain tissue samples from 29 secondary progressive (SP) and 7 primary progressive (PP) multiple sclerosis cases. B-cell follicles were detected in the meninges entering the cerebral sulci of 41.4% of the SPMS cases…

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