Menin induces apoptosis in murine embryonic fibroblasts.

  title={Menin induces apoptosis in murine embryonic fibroblasts.},
  author={Robert W. Schnepp and H. C. Mao and Stephen M. Sykes and Wei-Xing Zong and Albert C. Silva and Ping La and Xianxin Hua},
  journal={The Journal of biological chemistry},
  volume={279 11},
Multiple endocrine neoplasia type I (MEN1) is a hereditary tumor syndrome characterized by multiple endocrine and occasionally non-endocrine tumors. The tumor suppressor gene Men1, which is frequently mutated in MEN1 patients, encodes the nuclear protein menin. Although many tumor suppressor genes are involved in the regulation of apoptosis, it is unclear… CONTINUE READING