Menin and its interacting proteins: elucidation of menin function.

  title={Menin and its interacting proteins: elucidation of menin function.},
  author={Katalin Balogh and K{\'a}roly R{\'a}cz and Attila Pat{\'o}cs and L{\'a}szl{\'o} Hunyady},
  journal={Trends in endocrinology and metabolism: TEM},
  volume={17 9},
The multiple endocrine neoplasia type 1 (MEN1) gene is a tumor suppressor gene encoding a 610 amino acid nuclear protein, menin. Although mutations of the MEN1 gene are responsible for MEN 1 syndrome, the intracellular functions of menin have not been fully elucidated. Recent data suggest that interactions between menin and menin-interacting proteins have a role in physiological regulation of cell growth, control of the cell cycle and genome stability, and are potentially important in bone… CONTINUE READING


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