Meniere's disease

  title={Meniere's disease},
  author={Tsutomu Nakashima and Ilmari Pyykk{\"o} and Megan Anne Arroll and Margaretha L. Casselbrant and Carol A. Foster and Nauman Manzoor and Cliff A. Megerian and Shinji Naganawa and Yi-Ho Young},
  journal={Nature Reviews Disease Primers},
Meniere's disease (MD) is a disorder of the inner ear that causes vertigo attacks, fluctuating hearing loss, tinnitus and aural fullness. The aetiology of MD is multifactorial. A characteristic sign of MD is endolymphatic hydrops (EH), a disorder in which excessive endolymph accumulates in the inner ear and causes damage to the ganglion cells. In most patients, the clinical symptoms of MD present after considerable accumulation of endolymph has occurred. However, some patients develop symptoms… 

Current Understanding and Clinical Management of Meniere's Disease: A Systematic Review.

A systematic review on meniere's disease to update current knowledge, focusing on its mechanisms, diagnosis, comorbidities, and practical management.

Features of the diagnosis of meniere's disease on the example of a clinical case

This clinical case illustrates the importance of collecting a detailed medical history and examination of a patient with complaints of dizziness, hearing loss, tinnitus, and repeated vomiting, and the coordinated work of a multidisciplinary group is required.

Evolution of Meniere’s Disease from MD 1.0, via MD 1.5, to MD 2.0

Elder Meniere’s disease patients ultimately lose their vestibular function, and evolution of MD may progress from unilateral MD coupled with asymptomatic hydrops on opposite ear to bilateral MD, where the number 1.0-2.0 means the number of clinically affected ears.

Pediatric Meniere's disease.

Approach to Ménière disease management.

An updated approach to the diagnosis and management of Ménière disease is provided, detailing the natural course of MD and describing how to initiate medical therapy while awaiting consultation with otolaryngology-head and neck surgery.

Magnetic resonance imaging and Ménière’s disease—unavoidable alliance

MRI techniques and diagnostic criteria of endolymphatic hydrops are reviewed, the role of MRI in MD is discussed, and the current criteria of the disease remain symptom based.

Usefulness of Video Head Impulse Test Results in the Identification of Meniere's Disease

The objective of this manuscript is to review the different vHIT results in MD patients and discuss the usefulness of these findings in the identification of MD, how these results may be explained by pathophysiological mechanisms associated with MD, and finally provide directions for future studies.

The value of four stage vestibular hydrops grading and asymmetric perilymphatic enhancement in the diagnosis of Menière’s disease on MRI

A four-stage vestibular-cochlear EH and PE grading system in combination with cochlear PE assessment gives the best diagnostic accuracy to detect MD.

Gadolinium-enhanced MRI reveals dynamic development of endolymphatic hydrops in Ménière's disease




[Menière's Disease].

Current imaging studies using MRI have shown that hydropic ear disease is associated not only with the full triad of vertigo, hearing, loss and tinnitus/aural pressure, but also with inner ear symptoms that do not fulfill the clinical criteria of definite Menière's disease as set forth by the AAO-HNS.

Surgery for Menière’s Disease

If conservative management of the menière’s disease fails, then perfusion of the middle ear with dexamethasone when hearing is functional, followed by gentamicin when repeated injections have failed, or when hear is non-functional.

Ménière's disease.

This review describes the pathogenesis and etiology as well as the diagnosis and treatment of Ménière's disease, which is characterized by spontaneous attacks of vertigo, fluctuating sensorineural hearing loss, aural fullness, and tinnitus.

Ménière's disease: a reappraisal supported by a variable latency of symptoms and the MRI visualisation of endolymphatic hydrops

It is suggested that a 3T MRI measurement should be carried out in patients with sensory-neural hearing loss, vertigo and tinnitus, 4 h after the intravenous injection of a gadolinium-contrast agent to verify the inner ear pathology.

The basic science of Meniere's disease and endolymphatic hydrops

Recent advances in the understanding of the pathophysiology of symptom development in Meniere's disease have expanded the understanding and will allow for the development of targeted therapeutic interventions aimed at preventing the progression oochleovestibular deterioration.

Endolymphatic space size in patients with vestibular migraine and Ménière’s disease

It is indicated that endolymphatic space size is significantly different between patients with VM and vestibular MD.

Histopathology of Meniere's disease.

Positive pressure therapy for Ménière's disease or syndrome.

The primary outcome was control of vertigo; secondary outcomes were loss or gain of hearing, severity of tinnitus, perception of aural fullness, functional level, complications or adverse effects, and sick days.

Saccular dysfunction in Meniere's disease.

Monitoring the vestibular evoked myogenic potentials evoked by high level clicks on the Stemomastoid muscles in patients with unilateral Meniere's disease found that VEMP testing is useful for detecting patients at risk.