Meniere's disease: histopathology, cytochemistry, and imaging

@article{Ishiyama2015MenieresDH,
  title={Meniere's disease: histopathology, cytochemistry, and imaging},
  author={G Ishiyama and Ivan A. Lopez and A R Sepahdari and Akira Ishiyama},
  journal={Annals of the New York Academy of Sciences},
  year={2015},
  volume={1343}
}
Meniere's disease is a poorly understood, disabling syndrome causing spells of vertigo, hearing fluctuation, tinnitus, and aural fullness. In this paper, we present a review of the histopathology, cytochemistry, and imaging of Meniere's disease. Histopathology is significant for neuroepithelial damage with hair cell loss, basement membrane thickening, and perivascular microvascular damage. Cytochemical alterations are significant for altered AQP4 and AQP6 expression in the supporting cell, and… 
Current Understanding and Clinical Management of Meniere's Disease: A Systematic Review.
TLDR
A systematic review on meniere's disease to update current knowledge, focusing on its mechanisms, diagnosis, comorbidities, and practical management.
Identification of Potential Meniere's Disease Targets in the Adult Stria Vascularis
TLDR
Comparison of published datasets related to Meniere's disease in humans with previously published adult mouse stria vascularis single-cell and single-nucleus RNA-Seq datasets are compared to implicate potentially involved striaascularis (SV) cell types in MD to provide support for these implicated cell types.
Endolymphatic Hydrops in Fluctuating Hearing Loss and Recurrent Vertigo
TLDR
The percentage of patients with EH varies between groups, and it is minimal in the ISSNHL group and increases in groups with increasing fluctuating audiovestibular symptoms, with a rate of severe EH similar to the known rate of progression to definite MD in those groups, suggesting that presence of EH by MRI could be related to the risk of progressionto definite MD.
Magnetic Resonance Imaging Fails to Show Evidence of Endolymphatic Hydrops in a Case with Tumarkin's Otolithic Crisis
TLDR
A patient with Tumarkin’s otolithic crisis is reported in whom inner-ear MRI with intratympanic gadolinium administration during the acute attack did not reveal the presence of endolymphatic hydrops.
Trend for Ménière ʼ s Disease
TLDR
A review of the histopathology, cytochemistry, gene, blood-labyrinthine barrier and imaging of Ménièreʼs disease, a poorly understood disorder of the inner ear characterized by intermittent episodic vertigo, fluctuating hearing loss, ear fullness and tinnitus is presented.
Ménière’s Disease and Tinnitus
TLDR
Tinnitus is one of the Ménière’s disease clue symptoms, but by far less studied than ver‐ tigo or other types of dizziness, a fact that may impact on tinnitus diagnosis and treatment.
Vitamin D supplementation may improve symptoms in Meniere's disease.
Usefulness of Video Head Impulse Test Results in the Identification of Meniere's Disease
TLDR
The objective of this manuscript is to review the different vHIT results in MD patients and discuss the usefulness of these findings in the identification of MD, how these results may be explained by pathophysiological mechanisms associated with MD, and finally provide directions for future studies.
Clinical Features and Endolymphatic Hydrops in Patients With MRI Evidence of Hydrops
TLDR
MRI findings have relevance to the clinical severity, to a certain extent, but not vestibular symptoms, and the proposed diagnostic criteria based on clinical characteristics may be partially effective.
The blood labyrinthine barrier in the human normal and Meniere’s disease macula utricle
TLDR
The first ultrastructural analysis of the capillaries constituting the BLB in the human vestibular macula utricle from normal and Meniere’s disease is presented.
...
...

References

SHOWING 1-10 OF 47 REFERENCES
Macula utriculi in four cases with Meniere's disease.
TLDR
Four patients suffering from Meniere's disease were labyrinthectomized and maculae utriculi were removed and studied by electron microscopy, finding a few large intra-epithelial cysts, probably representing the final stage of the cystic degenerative process.
Investigations into the Cause of Canal Paresis in Meniere's Disease
TLDR
The findings in this investigation make a strong case for ampullary distortion disrupting the tenuous but vital cupulary attachment resulting in canal paresis, and explains an important clinical event in Meniere's disease on the basis of the only consistent histopathological finding, namely, membrane distension.
Vestibular sensory epithelium in Meniere's disease.
Utricle and horizontal semicircular canal ampulla removed during labyrinthectomy from 11 patients with advanced Meniere's disease were studied under light and electron microscope. In light microscopy
Histopathological and ultrastructural analysis of vestibular endorgans in Meniere's disease reveals basement membrane pathology
TLDR
Systematic histopathological analysis of vestibular endorgans acquired from labyrinthectomy in Meniere's disease demonstrated neuroepithelial degeneration which was highly correlated with an associated BM thickening.
Menière's disease.
TLDR
Meniere's disease causes recurrent vertigo, hearing loss, tinnitus, and fullness or pressure in the ear, which mainly affects adults aged 40-60 years and episodes can occur in clusters.
Visualization of Endolymphatic Hydrops in Patients With Meniere's Disease
TLDR
This work attempted to visualize how the intratympanically administered drug enters the inner ear of Meniere's disease patients.
Prosper Ménière and his disease.
  • R. Baloh
  • Medicine, Psychology
    Archives of neurology
  • 2001
TLDR
In 1861, Prosper Ménière presented a paper before the French Academy of Medicine in which he described a series of patients with episodic vertigo and hearing loss, and emphasized that vertigo could originate from damage to the inner ear.
Pathophysiology of Ménière's Syndrome: Are Symptoms Caused by Endolymphatic Hydrops?
  • S. Merchant, J. Adams, J. Nadol
  • Medicine
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • 2005
TLDR
Endolymphatic hydrops should be considered as a histologic marker for Ménière's syndrome rather than being directly responsible for its symptoms, consistent with the hypothesis that hydrops resulted from disordered fluid homeostasis caused by disruption of regulatory elements within the spiral ligament.
Histopathology of the vestibular end organs after intratympanic gentamicin failure for Meniere's disease
TLDR
This is the first report of the histopathology of the vestibular end organs following intratympanic gentamicin for intractable Meniere's disease and there was relative sparing of the utricular macula, compared with the cristae ampullares.
Drop attacks with Meniere's syndrome
We report the clinical features of 12 patients with drop attacks associated with Meniere's syndrome. Each described a sensation of being pushed, thrown, or knocked to the ground or a sudden illusion
...
...