Mendelian susceptibility to mycobacterial disease.

  title={Mendelian susceptibility to mycobacterial disease.},
  author={Lucy E. Cottle},
  journal={Clinical genetics},
  volume={79 1},
The host response to mycobacterial infection is mediated by the type I cytokine pathway (cell-mediated immunity). Deficiencies in this response result in susceptibility to poorly pathogenic mycobacterial species such as bacille Calmette-Guérin and environmental mycobacteria. In recent years a number of mutations in the genes encoding major components in the type I cytokine axis have been described which predispose to disseminated infection with these weakly virulent mycobacterial species… CONTINUE READING