Mendelian randomization studies in coronary artery disease.

  title={Mendelian randomization studies in coronary artery disease.},
  author={Henning Jansen and Nilesh J. Samani and Heribert Schunkert},
  journal={European heart journal},
  volume={35 29},
Epidemiological research over the last 50 years has discovered a plethora of biomarkers (including molecules, traits or other diseases) that associate with coronary artery disease (CAD) risk. Even the strongest association detected in such observational research precludes drawing conclusions about the causality underlying the relationship between biomarker and disease. Mendelian randomization (MR) studies can shed light on the causality of associations, i.e whether, on the one hand, the… CONTINUE READING