Corpus ID: 7754412

Mendelian proportions in a mixed population. 1908.

@article{Hardy2003MendelianPI,
  title={Mendelian proportions in a mixed population. 1908.},
  author={G. Hardy},
  journal={The Yale Journal of Biology and Medicine},
  year={2003},
  volume={76},
  pages={79 - 80}
}
  • G. Hardy
  • Published 2003
  • Medicine
  • The Yale Journal of Biology and Medicine
TO THE EDITOR OF SCIENCE: I am reluctant to intrude in a discussion concerning matters of which I have no expert knowledge, and I should have expected the very simple point which I wish to make to have been familiar to biologists. However, some remarks of Mr. Udny Yule, to which Mr. R.O. Punnett has called my attention, suggest that it may still be worth making. In the Proceedings of the Royal Society of Medicine (Vol. I., p. 165) Mr. Yule is reported to have suggested, as a criticism of the… Expand
R.A. Fisher. The relevance of the genetical theory of natural selection
Starting from the main statement that “. . . natural selection is not evolution. . . ”, R.A. Fisher built the foundation of the genetic theory of population in his famous work Genetical Theory ofExpand
A new variant of endemic pemphigus foliaceus in El-Bagre, Colombia: the Hardy-Weinberg-Castle law and linked short tandem repeats
TLDR
The penetrance of 10% or less in female patients 60 years of age or older indicates that hormones could protect younger females, and indicates that the best model of inheritance in this disease is a mixed model, with multifactorial effects within a recessive genotype. Expand
MTHFD1 polymorphism as maternal risk for neural tube defects: a meta-analysis
TLDR
Evidence is provided of the association between maternal MTHFD1 G1958A polymorphism and NTD susceptibility and that, compared with the mothers with GG genotype, the women with AA genotype had an increased risk of NTD in their offspring. Expand
Phylogenic analysis and forensic genetic characterization of Chinese Uyghur group via autosomal multi STR markers.
TLDR
These autosomal short tandem repeat loci were highly informative in Uyghur group and the multiplex PCR system could be used as a valuable tool for forensic caseworks and population genetic analysis. Expand
Drake’s rule as a consequence of approaching channel capacity
TLDR
A formal model for the storage of genetic information suggests that a genome of any species operates near its maximum informational storage capacity, and the mutation rate per-genome per-generation is near its upper limit, providing a simple explanation for Drake’s rule with minimal assumptions. Expand
Pragmatic Hypotheses in the Evolution of Science
TLDR
The introduction of pragmatic hypotheses allows the evolution of scientific theories based on statistical hypothesis testing to be interpreted using the narratological structure of hexagonal spirals, as defined by Pierre Gallais. Expand
Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline
Parkinson's disease is a neurodegenerative disorder which is in most cases of unknown etiology. Mutations of the Park‐2 gene are the most frequent cause of familial parkinsonism and parkin knockoutExpand
Evolutionary Explanations for Natural Language - Criteria from Evolutionary Biology
Theories of the evolutionary origins of language must be informed by empirical and theoretical results from a variety of different fields. Complementing recent su rveys of relevant work fromExpand
APOE genotype is associated with oral herpetic lesions but not genital or oral herpes simplex virus shedding
TLDR
Variation at the APOE locus may be associated with clinical manifestations of HSV-1 infection, but does not appear to correlate with herpes simplex viral reactivation in humans. Expand
Spontaneous Viral Load Decline and Subsequent Clearance of Chronic Hepatitis C Virus in Postpartum Women Correlates With Favorable Interleukin-28B Gene Allele
  • M. Hashem, R. Jhaveri, +6 authors S. El-Kamary
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2017
TLDR
IL28B-CC genotype and 12-month postpartum undetectable viremia were the best predictors for viral decline and subsequent clearance and should influence clinical decision making. Expand
...
1
2
...