Menaquinone biosynthesis potentiates haem toxicity in Staphylococcus aureus.

  title={Menaquinone biosynthesis potentiates haem toxicity in Staphylococcus aureus.},
  author={Catherine A. Wakeman and Neal D. Hammer and Devin L. Stauff and Ahmed S Attia and Laura L Anzaldi and Sergey I. Dikalov and Marion W Calcutt and Eric P Skaar},
  journal={Molecular microbiology},
  volume={86 6},
Staphylococcus aureus is a pathogen that infects multiple anatomical sites leading to a diverse array of diseases. Although vertebrates can restrict the growth of invading pathogens by sequestering iron within haem, S. aureus surmounts this challenge by employing high-affinity haem uptake systems. However, the presence of excess haem is highly toxic, necessitating tight regulation of haem levels. To overcome haem stress, S. aureus expresses the detoxification system HrtAB. In this work, a… CONTINUE READING


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