Menadione serves as a substrate for P-glycoprotein: implication in chemosensitizing activity.

@article{Oh2013MenadioneSA,
  title={Menadione serves as a substrate for P-glycoprotein: implication in chemosensitizing activity.},
  author={Seok-Jeong Oh and Hyo-Kyung Han and Keon-Wook Kang and Young-Joo Lee and Moo-Yeol Lee},
  journal={Archives of pharmacal research},
  year={2013},
  volume={36 4},
  pages={509-16}
}
Based on its chemosensitizing effect, we questioned whether menadione is an inhibitor or a substrate of P-glycoprotein (P-gp). To test this hypothesis, we assessed the effect of menadione on P-gp activity and examined the P-gp-dependency of cellular accumulation and cytotoxicity of menadione as well. Treatment with menadione resulted in the concentration-dependent increase of rhodamine 123 (Rh123) accumulation in P-gp-overexpressing MDCKII/MDR1 and NCI/ADR-RES cells, suggesting that menadione… CONTINUE READING
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