Menadione and cumene hydroperoxide induced cytotoxicity in biliary epithelial cells isolated from rat liver.

@article{Parola1990MenadioneAC,
  title={Menadione and cumene hydroperoxide induced cytotoxicity in biliary epithelial cells isolated from rat liver.},
  author={Maurizio Parola and Kerri Cheeseman and M E Biocca and Mario Umberto Dianzani and Timothy Frederick Slater},
  journal={Biochemical pharmacology},
  year={1990},
  volume={39 11},
  pages={1727-34}
}
Biliary epithelial cells (BEC) and parenchymal cells isolated from normal rat liver were exposed in vitro to a number of toxic compounds. BEC were found to be highly sensitive to concentrations of menadione (100 microM) and cumene hydroperoxide (10 microM) that are usually not effective as toxic agents in hepatocytes under normoxic conditions. On the other hand, BEC were not affected by concentrations of carbon tetrachloride or 7-ethoxycoumarin that are known to exert toxic effects on… CONTINUE READING

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