Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer.

@article{Roussos2011MenaI,
  title={Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer.},
  author={Evanthia T. Roussos and Michele Balsamo and Shannon K. Alford and Jeffrey B. Wyckoff and Bojana Gligorijevic and Yarong Wang and Maria Pozzuto and Robert Stobezki and Sumanta K Goswami and Jeffrey E Segall and Douglas A. Lauffenburger and Anne R. Bresnick and Frank B. Gertler and John S Condeelis},
  journal={Journal of cell science},
  year={2011},
  volume={124 Pt 13},
  pages={2120-31}
}
We have shown previously that distinct Mena isoforms are expressed in invasive and migratory tumor cells in vivo and that the invasion isoform (Mena(INV)) potentiates carcinoma cell metastasis in murine models of breast cancer. However, the specific step of metastatic progression affected by this isoform and the effects on metastasis of the Mena11a isoform, expressed in primary tumor cells, are largely unknown. Here, we provide evidence that elevated Mena(INV) increases coordinated streaming… CONTINUE READING