Men and women differ in inflammatory and neuroendocrine responses to endotoxin but not in the severity of sickness symptoms

  title={Men and women differ in inflammatory and neuroendocrine responses to endotoxin but not in the severity of sickness symptoms},
  author={H. Engler and S. Benson and A. Wegner and I. Spreitzer and S. Elsenbruch},
  journal={Brain, Behavior, and Immunity},
  • H. Engler, S. Benson, +2 authors S. Elsenbruch
  • Published 2016
  • Medicine, Biology
  • Brain, Behavior, and Immunity
  • Impaired mood and increased anxiety represent core symptoms of sickness behavior that are thought to be mediated by pro-inflammatory cytokines. Moreover, excessive inflammation seems to be implicated in the development of mood/affective disorders. Although women are known to mount stronger pro-inflammatory responses during infections and are at higher risk to develop depressive and anxiety disorders compared to men, experimental studies on sex differences in sickness symptoms are scarce. Thus… CONTINUE READING
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