Memory training alters hippocampal neurochemistry in healthy elderly.

  title={Memory training alters hippocampal neurochemistry in healthy elderly.},
  author={Michael J. Valenzuela and Megan Jones and Wei Wen and Caroline Rae and Scott K. Graham and Ronald C Shnier and Perminder S. Sachdev},
  volume={14 10},
Accumulating epidemiological evidence supports the notion of brain reserve, but there has been no investigation of neurobiological change associated with brief mental activation training in humans. Healthy older individuals were therefore investigated with magnetic resonance spectroscopy (MRS) in different brain regions before and after 5 weeks of focused memory training. Recall of a test-word list of > 23 items was achieved accompanied by elevation of creatine and choline signals in the… CONTINUE READING


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