Memory reconsolidation: an update

  title={Memory reconsolidation: an update},
  author={Karim Nader and Einar {\"O} Einarsson},
  journal={Annals of the New York Academy of Sciences},
Memory consolidation refers to the stabilization that a new memory has to undergo in order to persist. Recently, this dominant view of memory has been challenged by renewed interest in reconsolidation, where consolidated memories return to a transient unstable state following their retrieval, from which they must again stabilize in order to persist. In this review, we discuss how reconsolidation is supported by the same line of evidence as consolidation and recent findings of boundary… 

Reconsolidation of memory: A decade of debate

Repeated Labilization-Reconsolidation Processes Strengthen Declarative Memory in Humans

This work proposes central concepts for the reconsolidation process, emphasizing its biological role and the parametrical constrains for this function to be operative.

Characterization of spatial memory reconsolidation.

This study finds that protein synthesis is necessary for reconsolidation to occur in the hippocampal CA3 region after reactivation of partially acquired and old memories but not for strongly acquired and recent memories, and demonstrates the importance of the knowledge of the task on the dynamic nature of memory reconsolidations processing.

Is Reconsolidation a General Property of Memory?

It is discussed how inconsistent results can be reconciled and what information is needed to uncover for the general use of reconsolidation.

Towards a unified model of Pavlovian conditioning: a solution to the reconsolidation problem

This work believes that the Theta-Regulated Attention Theory and the "Neurolocator" model as its implementation can meet the above requirements and are able to answer the most difficult and unresolved outstanding questions of consolidation/reconsolidation studies.

A computational model of systems memory consolidation and reconsolidation

A neural model based on well‐documented mechanisms of synaptic plasticity and stability is proposed and a computational implementation is described that demonstrates the model's ability to account for a range of findings from the systems consolidation and reconsolidation literature.



A single standard for memory: the case for reconsolidation

It is established that the same operational definitions and types of evidence underpin the deduction of both reconsolidation and consolidation, thus validating the extrapolation that post-retrieval memory plasticity reflects processes akin to those that stabilized the memory following acquisition.

Reconsolidation: maintaining memory relevance

Reconsolidation reconsidered

A retrieval-oriented conceptualization is offered to account for the temporal gradient and the “reconsolidation” phenomena and shows that inhibition of protein synthesis in the lateral and basal nuclei of the amygdala immediately following the reactivation of old memory will induce retrograde amnesia.

Commentary — reconsolidation: Memory involves far more than 'consolidation'

Other behavioural observations indicate that even this modification to consolidation theory may be insufficient to describe the dynamic properties of memory.

The neurobiology of consolidations, or, how stable is the engram?

  • Y. Dudai
  • Biology
    Annual review of psychology
  • 2004
A heated debate has been revitalized on whether memories become labile and must undergo some form of renewed consolidation every time they are activated, and on fundamental issues concerning the nature of the memory trace, its maturation, persistence, retrievability, and modifiability.

Stability of Retrieved Memory: Inverse Correlation with Trace Dominance

It is reported that in both conditioned taste aversion in the rat and fear conditioning in the medaka fish, the stability of retrieved memory is inversely correlated with the control of behavior by that memory.

Fading in.

Some recent work will be discussed that has gone beyond the shortcomings of previous experimental approaches to strongly suggest that amnesia can be due to a retrieval impairment that can be overcome with a reminder--an example of memories fading in.

Independent Cellular Processes for Hippocampal Memory Consolidation and Reconsolidation

By infusing antisense oligodeoxynucleotides into the hippocampus of rats, this work shows that consolidation and reconsolidation are doubly dissociable component processes of memory.