Memory performance in healthy elderly without Alzheimer's disease: effects of time and apolipoprotein-E.

Abstract

Transgenic mice expressing human APOE-epsilon4 develop an age-dependent decline in memory without pathological features of Alzheimer's disease (AD). This implicates APOE in the maintenance of memory during normal senescence, but parallel human studies are limited because longitudinal investigations of memory usually do not exclude patients with AD or… (More)

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@article{Mayeux2001MemoryPI, title={Memory performance in healthy elderly without Alzheimer's disease: effects of time and apolipoprotein-E.}, author={Richard P. Mayeux and S. A. Small and M. Tang and Benjamin Tycko and Yaakov Stern}, journal={Neurobiology of aging}, year={2001}, volume={22 4}, pages={683-9} }