Memory of mice and men: CD8+ T-cell cross-reactivity and heterologous immunity.

@article{Selin2006MemoryOM,
  title={Memory of mice and men: CD8+ T-cell cross-reactivity and heterologous immunity.},
  author={Liisa K. Selin and Michael A. Brehm and Yuri N. Naumov and Markus Cornberg and Sung-kwon Kim and Shalyn Catherine Clute and Raymond M. Welsh},
  journal={Immunological reviews},
  year={2006},
  volume={211},
  pages={164-81}
}
The main functions of memory T cells are to provide protection upon re-exposure to a pathogen and to prevent the re-emergence of low-grade persistent pathogens. Memory T cells achieve these functions through their high frequency and elevated activation state, which lead to rapid responses upon antigenic challenge. The significance and characteristics of memory CD8+ T cells in viral infections have been studied extensively. In many of these studies of T-cell memory, experimental viral… CONTINUE READING

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