Memory of Pain: The Effect of Perineural Resiniferatoxin

@article{Kissin2006MemoryOP,
  title={Memory of Pain: The Effect of Perineural Resiniferatoxin},
  author={Igor Kissin and Cristina F. Freitas and Edwin L. Bradley},
  journal={Anesthesia \& Analgesia},
  year={2006},
  volume={103},
  pages={721-728}
}
The long-lasting imprint of acute pain in the central nervous system may contribute to the transition of acute pain to chronicity. The long-term potentiation (which is proposed as a mechanism of memory) and central sensitization were each reported as a form of synaptic plasticity, and both can be initiated by stimulation of C fibers. In the current study, we assessed nociceptive memory regarding hyperalgesia by measuring distant hyperalgesia after repeated carrageenan-induced inflammation. This… 

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