Memory inflation: continuous accumulation of antiviral CD8+ T cells over time.

@article{Karrer2003MemoryIC,
  title={Memory inflation: continuous accumulation of antiviral CD8+ T cells over time.},
  author={Urs Karrer and Sophie Sierro and Markus Wagner and Annette Oxenius and Hartmut Hengel and Ulrich Koszinowski and Rodney E. Phillips and Paul Klenerman},
  journal={Journal of immunology},
  year={2003},
  volume={170 4},
  pages={2022-9}
}
CD8+ T lymphocytes play an important role in the control of intracellular pathogens during both acute and persistent infections. This is particularly true in the case of persistent herpesviruses such as human CMV, which are typified by large virus-specific CD8+ T cell populations during viral latency. To understand the origin of these populations and the factors shaping them over time, we investigated the CD8+ T cell response after murine CMV (MCMV) infection. The kinetics of the acute response… CONTINUE READING