Memory improving actions of gabapentin in mice: possible involvement of central muscarinic cholinergic mechanism.

@article{Boccia2001MemoryIA,
  title={Memory improving actions of gabapentin in mice: possible involvement of central muscarinic cholinergic mechanism.},
  author={M M Boccia and Gabriela Beatriz Acosta and Carlos Mar{\'i}a Baratti},
  journal={Neuroscience letters},
  year={2001},
  volume={311 3},
  pages={153-6}
}
Male CF-1 mice were tested 48 h after training on a one trial step-through inhibitory avoidance task. Immediately post-training, intraperitoneal (i.p.) injections of the antiepileptic gabapentin (1-(aminomethyl) cyclohexaneacetic acid) (GBP, 10 mg/kg) enhanced retention performance. The effect was prevented by atropine, a central muscarinic cholinergic receptor antagonist (0.5 mg/kg, i.p.) administered after training but 10 min prior to GBP treatment. In contrast, neither methylatropine (0.5 mg… CONTINUE READING
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