Memory for places learned long ago is intact after hippocampal damage

  title={Memory for places learned long ago is intact after hippocampal damage},
  author={Edmond Teng and Larry R. Squire},
The hippocampus is part of a system of structures in the medial temporal lobe that are essential for memory. One influential view of hippocampal function emphasizes its role in the acquisition and retrieval of spatial knowledge,. By this view, the hippocampus constructs and stores spatial maps and is therefore essential for learning and remembering places, including those learned about long ago. We tested a profoundly amnesic patient (E.P.), who has virtually complete bilateral damage to the… 
Remote spatial memory in an amnesic person with extensive bilateral hippocampal lesions
Remote spatial memory in K.C, a patient with bilateral hippocampal lesions and amnesia for autobiographical events, suggests that the hippocampus is not crucial for maintenance and retrieval of remotely formed spatial representations of major landmarks, routes, distances and directions, but is necessary for specifying location details, regardless of when they were acquired.
Memory for familiar environments learned in the remote past: fMRI studies of healthy people and an amnesic person with extensive bilateral hippocampal lesions
The distinction between recent and remote memory may apply as much to spatial theories of hippocampal function as it does to theories emphasizing the role of the hippocampus in other types of explicit memory.
Map reading, navigating from maps, and the medial temporal lobe
It is suggested that the hippocampus is not needed to carry out the spatial computations needed for map reading and navigating from maps, and the impairment in map reading associated with large MTL lesions may depend on damage in or near the parahippocampal cortex.
Dynamics of Hippocampal-Cortical Interactions During Memory Consolidation: Insights from Functional Brain Imaging
The findings show that memory processing and consolidation require a time-dependent hippocampal-cortical dialogue, ultimately enabling structured cortical networks to mediate recall and use of cortically stored remote memories independently.
On the role of the hippocampus in the acquisition, long-term retention and semanticisation of memory
A coherent view of what makes a task hippocampallydependent at acquisition and how this relates to its long-term fate is formulated and conceptualising episodic and semantic memory as representing points on a continuum of memory types appears viable.
Impaired remote spatial memory after hippocampal lesions despite extensive training beginning early in life
Even after extended training beginning early in life, and with a prolonged training–surgery interval, hippocampal lesions impair performance in the water maze task.
Consolidation of memory
Animal studies support the notion that information is stored in both hippocampal and extrahipocampal sites, and that retrieval from different sites involves access to different kinds of information, and help to explain why graded retrograde amnesia is sometimes seen after brain damage.
Hippocampal area CA1 and remote memory in rats.
A discrete lesion targeting area CA1, the sole output of the hippocampus to neocortex, was developed and tested the effects of this lesion on recent and remote memory in the watermaze task, in context fear conditioning, and in trace fear conditioning; in all three tasks, recent andRemote memory were similarly impaired after CA1 lesions.
New views on old memories: re-evaluating the role of the hippocampal complex
Hippocampal-dependent spatial and episodic memory in humans.
The role of the human hippocampus in spatial and episodic memory was investigated using methods from neuropsychology, experimental psychology and functional magnetic resonance imaging, and the relationship between viewpoint independence, multi-modal context and semantic embedding in retrieval was discussed.


Equivalent impairment of spatial and nonspatial memory following damage to the human hippocampus
This study compared spatial and nonspatial memory in amnesic patients with lesions of the hippocampal formation or diencephalon and suggested that the hippocampus is not especially involved in spatial memory, while cognitive mapping in its most abstract sense may describe hippocampal function.
Recalling Routes around London: Activation of the Right Hippocampus in Taxi Drivers
PET was used to examine the neural substrates of topographical memory retrieval in licensed London taxi drivers of many years experience while they recalled complex routes around the city, and activation of a network of brain regions, including the right hippocampus, suggests that the hippocampus is involved in the processing of spatial layouts established over long time courses.
What does the hippocampus really do?
  • L. Jarrard
  • Biology, Psychology
    Behavioural Brain Research
  • 1995
Learning to find your way: a role for the human hippocampal formation
A positron emission tomography study designed to investigate the regional cerebral blood flow changes associated with topographical memory formation in humans, i.
Memory in monkeys severely impaired by combined but not by separate removal of amygdala and hippocampus
A discrepancy between the clinical and animal literature could indicate a true evolutionary shift in the functions of the hippocampus, or, at the other extreme, it could simply reflect the use of incommensurate measures across species.
Place navigation impaired in rats with hippocampal lesions
It is reported that, in addition to a spatial discrimination impairment, total hippocampal lesions also cause a profound and lasting placenavigational impairment that can be dissociated from correlated motor, motivational and reinforcement aspects of the procedure.