Memory failure has different mechanisms in subcortical stroke and Alzheimer's disease

  title={Memory failure has different mechanisms in subcortical stroke and Alzheimer's disease},
  author={Bruce R. Reed and J. L. Eberling and Dan Mungas and Michael W. Weiner and W. J. Jagust},
  journal={Annals of Neurology},
Patients with extensive subcortical cerebrovascular disease may have impaired memory, often despite the absence of medial temporal or diencephalic strokes. In this group, episodic memory failure may arise from frontal lobe dysfunction based on disruption of frontosubcortical loops caused by lacunae. We tested this idea by studying cognitively impaired subcortical stroke (CIS) patients and Alzheimer's disease (AD) patients with [18F]‐fluorodeoxyglucose positron emission tomography using a… 
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  • L. Bäckman
  • Psychology, Biology
    Canadian journal of psychiatry. Revue canadienne de psychiatrie
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