Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease

@inproceedings{Ricciarelli2017MemoryenhancingEO,
  title={Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease},
  author={Roberta Ricciarelli and Chiara Brullo and Jos Prickaerts and Ottavio Arancio and Carla Villa and Claudia Rebosio and Elisa Calcagno and Matilde Balbi and Britt T. J. van Hagen and Elentina K. Argyrousi and Hong Zhang and Maria Adelaide Pronzato and O. A. Bruno and Ernesto Fedele},
  booktitle={Scientific reports},
  year={2017}
}
Memory loss characterizes several neurodegenerative disorders, including Alzheimer's disease (AD). Inhibition of type 4 phosphodiesterase (PDE4) and elevation of cyclic adenosine monophosphate (cAMP) has emerged as a promising therapeutic approach to treat cognitive deficits. However, PDE4 exists in several isoforms and pan inhibitors cannot be used in… CONTINUE READING