Memory effector (CD45RO+) and cytotoxic (CD8+) T cells appear early in the margin zone of spreading psoriatic lesions in contrast to cells expressing natural killer receptors, which appear late.

@article{Vissers2004MemoryE,
  title={Memory effector (CD45RO+) and cytotoxic (CD8+) T cells appear early in the margin zone of spreading psoriatic lesions in contrast to cells expressing natural killer receptors, which appear late.},
  author={Wynand H P M Vissers and C H M Arndtz and Leon Muys and Piet E J van Erp and Elke M G J De jong and Peter C. M. van de Kerkhof},
  journal={The British journal of dermatology},
  year={2004},
  volume={150 5},
  pages={852-9}
}
BACKGROUND An influx of immunocytes, increased epidermal proliferation and abnormal keratinization are hallmarks of the psoriatic lesion. T-lymphocyte subsets in particular activated effector memory T cells and natural killer (NK) T cells have been suggested to play an important role in the pathogenesis of psoriasis. OBJECTIVES In the present study we investigated the number of T-cell subsets (CD4, CD8, CD45RO, CD45RA, CD2, CD25), cells expressing NK receptors (CD94 and CD161), the… CONTINUE READING

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