Memory deficits in Alzheimer's patients: A comprehensive review

@article{Carlesimo2005MemoryDI,
  title={Memory deficits in Alzheimer's patients: A comprehensive review},
  author={Giovanni Augusto Carlesimo and Marlene Oscar-Berman},
  journal={Neuropsychology Review},
  year={2005},
  volume={3},
  pages={119-169}
}
Despite considerable experimental work on Alzheimer's disease (AD), the underlying cognitive mechanisms as well as the precise localization of neuropathological changes critical for memory loss remains undefined. A review of the neuropsychological literature on long-term memory deficits in AD patients suggests that AD patients display (a) a pervasive deficit of explicit memory, (b) a partial deficiency of implicit memory for verbal and visuoperceptual material (as measured by repetition priming… 
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The results show that explicit spatial memory is impaired in AD patients compared with a control group, however, no group difference was found on implicit spatial function, indicating that spared implicit memory in AD extends to the spatial domain, while the explicitatial memory function deteriorates.
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The results indicate that Alzheimer's disease patients show differences in the functional networks underlying memory over short delays, mostly in brain areas known to support phonological processing or executive functioning.
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  • Psychology, Biology
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  • 2004
TLDR
The investigation of human memory in neurodegenerative disorders suggests that the interaction of networks subserving episodic memory, semantic memory, and working memory contributes to higher level cognition and results in the fundamental homeostatic processes of recall and learning.
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Although mild AD and early PD both impair working memory, the deficits may be related to the interruption of different processes that contribute to WM performance, which may be secondary to deficits in other cognitive capacities, including semantic memory.
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TLDR
Comparison on tasks routinely used in the neuropsychological assessment of episodic memory to evaluate which test is more sensitive in predicting subsequent progression to AD in patients with amnestic mild cognitive impairment showed that stable a-MCI patients performed worse on word list than on story recall, whereas patients who later converted to AD tended to have similar poor memory performance on both tasks.
Verbal learning in Alzheimer's dementia
Abstract Many recent findings in Western countries suggest that episodic recall is the most sensitive discriminator between patients with mild Alzheimer disease (AD) and the normal elderly, while
Verbal learning in Alzheimer's dementia.
  • A. Au, A. Chan, H. Chiu
  • Psychology, Biology
    Journal of the International Neuropsychological Society : JINS
  • 2003
TLDR
This first to examine in detail the episodic memory of Chinese AD patients in Hong Kong with a locally developed list learning test, comparing procedures that do or do not encourage the use of semantic organization found semantic clustering in the blocked condition to be the best predictor.
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