Memory deficits in APP23/Abca1+/− mice correlate with the level of Aβ oligomers

  title={Memory deficits in APP23/Abca1+/− mice correlate with the level of Aβ oligomers},
  author={Iliya Lefterov and Nicholas F. Fitz and Andrea A Cronican and Preslav I Lefterov and Matthias Staufenbiel and Radosveta Koldamova},
  booktitle={ASN neuro},
ABCA1, a member of the ATP-binding cassette family of transporters, lipidates ApoE (apolipoprotein A) and is essential for the generation of HDL (high-density lipoprotein)-like particles in the CNS (central nervous system). Lack of Abca1 increases amyloid deposition in several AD (Alzheimer's disease) mouse models. We hypothesized that deletion of only one copy of Abca1 in APP23 (where APP is amyloid precursor protein) AD model mice will aggravate memory deficits in these mice. Using the Morris… CONTINUE READING


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