Memory consolidation, retrograde amnesia and the hippocampal complex

@article{Nadel1997MemoryCR,
  title={Memory consolidation, retrograde amnesia and the hippocampal complex},
  author={Lynn Nadel and Morris Moscovitch},
  journal={Current Opinion in Neurobiology},
  year={1997},
  volume={7},
  pages={217-227}
}
Results from recent studies of retrograde amnesia following damage to the hippocampal complex of human and non-human subjects have shown that retrograde amnesia is extensive and can encompass much of a subject's lifetime; the degree of loss may depend upon the type of memory assessed. These and other findings suggest that the hippocampal formation and related structures are involved in certain forms of memory (e.g. autobiographical episodic and spatial memory) for as long as they exist and… Expand
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References

SHOWING 1-10 OF 104 REFERENCES
Retrograde amnesia and memory consolidation: a neurobiological perspective
TLDR
A simple neural network model is inspired that produces behavior consistent with experimental data and makes ideas about memory consolidation more concrete about how memory consolidation might actually occur. Expand
The medial temporal lobe memory system
TLDR
The medial temporal lobe memory system is needed to bind together the distributed storage sites in neocortex that represent a whole memory, but the role of this system is only temporary, as time passes after learning, memory stored in neoc cortex gradually becomes independent of medialporal lobe structures. Expand
Which brain regions are critically involved in the retrieval of old episodic memory?
TLDR
While current opinion assumes a strong anatomical interdigitation in the processing of either kind of memory, recent single case reports and results obtained with the positron emission tomographic subtraction method indicate the likely existence of a dissociation. Expand
Different degrees of impairment in anterograde retrograde memory and recall/recognition performance in a transient global amnesic case
Abstract A 59-year-old patient with transient global amnesia was tested neuropsychologically during and after the attack. During the attack the patient manifested major problems with anterograde, but… Expand
Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus
TLDR
This is the first reported case of amnesia following a lesion limited to the hippocampus in which extensive neuropsychological and neuropathological analyses have been carried out. Expand
Frontal lobes and the temporal organization of memory.
TLDR
It has now been established that the frontal cortex participates in judgements of the temporal order of recent events and of their frequency of occurrence, as well as in the planning and monitoring of the execution of self-determined sequences of responses. Expand
Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans.
  • L. Squire
  • Psychology, Medicine
  • Psychological review
  • 1992
TLDR
The role of the hippocampus is considered, which is needed temporarily to bind together distributed sites in neocortex that together represent a whole memory. Expand
Memory, amnesia, and frontal lobe dysfunction
Lesions restricted to the frontal lobes do not ordinarily produce an amnesic syndrome in man. However, recent research has demonstrated that amnesic patients who are characterized by signs of frontal… Expand
Differentiating the roles of the hippocampal complex and the neocortex in long-term memory storage: evidence from the study of semantic dementia and Alzheimer's disease.
TLDR
It is demonstrated that patients with semantic dementia, who have relative sparing of the hippocampal complex, show a pattern of preserved recent memories and impaired distant memories. Expand
Loss of remote memory: a cognitive neuropsychological perspective
TLDR
Profound loss of autobiographical memory, with relative sparing of knowledge of word meaning, facts about other people and personal semantic information, may arise from either disruption of thematic retrieval frameworks or a loss of individual memory traces. Expand
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