Memory-Prediction Errors and Their Consequences in Schizophrenia


Cognitive deficits play a central role in the onset of schizophrenia. Cognitive impairment precedes the onset of psychosis in at least a subgroup of patients, and accounts for considerable dysfunction. Yet cognitive deficits as currently measured are not significantly related to hallucinations and delusions. Part of this counterintuitive absence of a relationship may be caused by the lack of an organizing principle of cognitive impairment in schizophrenia research. We review literature suggesting that a system of memory-based prediction is central to human perception, thought and action , and forward the notion that many of the symptoms of schizophrenia are a result of a failure of this system.

DOI: 10.1007/s11065-009-9106-1

5 Figures and Tables

Citations per Year

53 Citations

Semantic Scholar estimates that this publication has 53 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Kraus2009MemoryPredictionEA, title={Memory-Prediction Errors and Their Consequences in Schizophrenia}, author={Michael S. Kraus and Richard Keefe and Ranga K. R. Krishnan}, journal={Neuropsychology Review}, year={2009}, volume={19}, pages={336-352} }