Memory Extinction, Learning Anew, and Learning the New: Dissociations in the Molecular Machinery of Learning in Cortex

@article{Berman2001MemoryEL,
  title={Memory Extinction, Learning Anew, and Learning the New: Dissociations in the Molecular Machinery of Learning in Cortex},
  author={Diego E Berman and Yadin Dudai},
  journal={Science},
  year={2001},
  volume={291},
  pages={2417 - 2419}
}
The rat insular cortex (IC) subserves the memory of conditioned taste aversion (CTA), in which a taste is associated with malaise. When the conditioned taste is unfamiliar, formation of long-term CTA memory depends on muscarinic and β-adrenergic receptors, mitogen-activated protein kinase (MAPK), and protein synthesis. We show that extinction of CTA memory is also dependent on protein synthesis and β-adrenergic receptors in the IC, but independent of muscarinic receptors and MAPK. This… 
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Pharmacological Studies of the Molecular Basis of Memory Extinction
Retrieval procedures, if carried out without reinforcement, initiate memory extinction. The extinction of one- trial avoidance learning requires glutamate NMDA receptors, calcium-calmodulin dependent…
Short Communication A role for prefrontal cortex in the extinction of a conditioned taste aversion
TLDR
As rats reached 90% reacceptance of a tastant that had previously been associated with lithium chloride-induced malaise, c-Fos protein expression increased dramatically as compared to animals with active CTAs, animals without CTAs or animals drinking SAC for the first time.
Involvement of the insular cortex in retention of conditioned taste aversion is not time dependent
Memory of Conditioned Taste Aversion Is Erased by Inhibition of PI3K in the Insular Cortex
TLDR
The present data add new evidence to suggest that PI3K is engaged in consolidation of aversive memories, as its inhibition is associated with erasure of CTA memory.
LTD at amygdalocortical synapses as a novel mechanism for hedonic learning
TLDR
It is reported that CTA was associated with decreased expression of immediate early genes in rat GC of both sexes, and with reduced amplitude of BLA-GC synaptic responses, pointing to long-term depression (LTD) as a mechanism for learning.
LTD at amygdalocortical synapses as a novel mechanism for hedonic learning
TLDR
It is reported that CTA was associated with decreased expression of immediate early genes in rat GC of both sexes, and with reduced amplitude of BLA-GC synaptic responses, pointing to long term depression (LTD) as a mechanism for learning.
The amygdalar circuit that acquires taste aversion memory differs from the circuit that extinguishes it
TLDR
Double dissociation analysis of the role of the central (CeA) and the basolateral (BLA) nuclei of the rat's amygdala in the acquisition and extinction, respectively, of conditioned taste aversion shows that the amygdalar circuit that acquires taste aversion memory differs functionally from the circuit that extinguishes it.
Differential involvement of cortical muscarinic and NMDA receptors in short‐ and long‐term taste aversion memory
TLDR
Results suggest that activation of muscarinic receptors in the insular cortex is involved in the acquisition of taste memory, whereas NMDA receptors participate in taste memory consolidation, demonstrating that different neurochemical mechanisms subserve different memory phases.
A role for prefrontal cortex in the extinction of a conditioned taste aversion
Dynamic processing of taste aversion extinction in the brain
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References

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