Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria.

@article{Schmidt2008MemoryCT,
  title={Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria.},
  author={Nathan W Schmidt and Rebecca L. Podyminogin and Noah S Butler and Vladimir P Badovinac and Brad J Tucker and Keith S. Bahjat and Peter M. Lauer and Arturo Reyes-Sandoval and Claire L. Hutchings and Anne C Moore and Sarah C Gilbert and Adrian V S Hill and Lyric C. Bartholomay and John T Harty},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 37},
  pages={
          14017-22
        }
}
Infection of mice with sporozoites of Plasmodium berghei or Plasmodium yoelii has been used extensively to evaluate liver-stage protection by candidate preerythrocytic malaria vaccines. Unfortunately, repeated success of such vaccines in mice has not translated readily to effective malaria vaccines in humans. Thus, mice may be used better as models to dissect basic parameters required for immunity to Plasmodium-infection than as preclinical vaccine models. In turn, this basic information may… CONTINUE READING

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Malaria vaccines: the stage we are at

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